To KP or not to KP; Challenging Perceptions of Neonatal Sepsis


  • Rosie Roots St Helier Hospital
  • E Senkal St. Helier Hospital
  • T Soribe St. Helier Hospital
  • S Yasin St. Helier Hospital


EONs, Kaizer Permanente



Current local guidelines for early onset neonatal sepsis are based on the 2012 NICE guidelines. Some trusts have transitioned to the Kaizer Permanente neonatal sepsis risk stratification tool. In our cohort, would the number of ultimately negative screens be reduced, without positive screens being missed if we applied KP?


Badgernet was used to identify all babies who were treated with IV antibiotics in June and July 2021. Management was compared to our local guideline. We then ran each case through the KP neonatal sepsis calculator.


66 babies were treated for EONS; this is 56% of live births, a 41% increase on 2019. 23 of these cases had positive screens, resulting in a number needed to treat of 3. 56% of screens were based on clinical indications in baby only. 52 of the cases were suitable to be run through he KP tool. Sensitivity of KP in our cohort was 35% (CI 0.14-0.55) and specificity was 84% (CI 0.71-0.96), p value 0.02. We found there was potential to reduce total screens by 84% however this would result in a false negative rate of 65%.


The perception that most EONS screens are based on maternal factors underpins the KP tool. However majority of screens at our unit were based on clinical baby factors; hence it is no surprise therefore that a tool focussed mainly on maternal risk factors has a high false negative rate. The clinical side of the tool would need to be modified for use in our cohort.




How to Cite

Roots, R., Senkal, E. ., Soribe, T., & Yasin, S. (2022). To KP or not to KP; Challenging Perceptions of Neonatal Sepsis. London Paediatrics, 1(1). Retrieved from